What painkillers can you use with Misoprostol?

You can use painkillers like Ibuprofen (Motrin) and Acetaminophen (Tylenol) with Misoprostol along with a little food, but do not use any muscle relaxers.

After taking Misoprostol, for some people the pain and uterine cramps can be very intense. For other people it is not intense at all. It is difficult to know how much pain you should expect when you take Misoprostol yourself.

As a precaution, we suggest that you take painkillers approximately 1 hour before taking Misoprostol. We also recommend eating a little bit of food with the painkiller medications.

Painkillers that work well with Misoprostol:

  1. Ibuprofen (Motrin)
  2. Acetaminophen (Tylenol)
  3. OR both medications together (they work differently so you can take the maximum dose of both medications on the same day)

Can I take Ibuprofen with Misoprostol?

You can take Ibuprofen (Motrin) with Misoprostol. You can take up to 800mg of Ibuprofen up to 3 times in 24 hours (total of 2400mg per 24 hours). Take the medication with a little food.

Can I take Tylenol after taking Misoprostol?

You can take Tylenol with Misoprostol. You can take up to 1000mg of Acetaminophen (Tylenol) up to 3 times in 24 hours (total of 3000mg per 24 hours). Take the medication with a little food.

Can you take a muscle relaxer with Misoprostol?

Do NOT use any muscle relaxers or anti-spasmodics with Misoprostol. As the Misoprostol makes your uterus contract, muscle relaxers and anti-spasmodics will interfere with the abortion process.